Publications 2006-2009

  • M. Rohe, M. Synowitz, R. Glass, S.M. Paul, A. Nykjaer, T.E. Willnow. Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J. Neurosci., in press

  • E.M. Quistgaard, S.S. Thirup. Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families. BMC Struct Biol. 2009,13; 9:46.

  • M.K. Raarup, A.W. Fjorback, S.M. Jensen, H.K. Müller, M.M. Kjaergaard, H. Poulsen, O. Wiborg, J.R. Nyengaard. Enhanced yellow fluorescent protein photoconversion to a cyan fluorescent protein-like species is sensitive to thermal and diffusion conditions. J. Biomed. Opt. 2009, 14:34-39.

  • R. Spoelgen, K.W. Adams, M. Koker, A.V. Thomas, O.M. Andersen, P.J. Hallett, K.K. Bercury, D.F. Joyner, M. Deng, W.H. Stoothoff, D.K. Strickland, T.E. Willnow, B.T. Hyman. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience 2009, 158:1460-8.

  • M. Holm, J. Nieto-Gonzalez, I. Vardya, C. Vaegter, A. Nykjaer, K. Jensen. Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus. J. Neurosci. 2009, 29:12412-8.

  • R. Botta, S. Lisi, A. Pinchera, F. Giorgi, C. Marcocci, A.R. Taddei, A.M. Fausto,
    N. Bernardini, C. Ippolito, L. Mattii, L. Persani, T. de Filippis, D. Calebiro, P. Madsen, C. M. Petersen, M. Marino. Sortilin is a putative post-endocytic receptor of thyroglobulin. Endocrinology 2009; 150:509-518.

  • S.E. Dodson, O.M. Andersen, V. Karmali, J.J. Fritz, D. Cheng, J. Peng, A.I. LeveyI, T.E. Willnow, J.J. Lah JJ. Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J. Neurosci. 2008, 28:12877-86.

  • T.E. Willnow, C.M. Petersen, A. Nykjær. VPS10P-domain receptors – regulators of neuronal viability and function. Nature Reviews (Neuroscience) 2008; 9: 899-909.

  • E.M. Quistgaard, P. Madsen, M.K. Grøftehauge, P. Nissen, C.M. Petersen, S. Thirup. Ligands binds to Sortilin in the tunnel of a 10 bladed b-propeller domain. Nature Struct. Mol. Biol. 2009, 16:96-98.

  • S.K. Nilsson, S. Christensen, M.K. Raarup, R.O. Ryan, M.S. Nielsen, G. Olivecrona. Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families. J. Biol. Chem. 2008, 283: 25920-7.

  • M.S. Nielsen, S.J. Keat, J.W. Hamati, P. Madsen, J.J. Gutzmann, A. Engelsberg, K.M. Pedersen, C. Gustafsen, A. Nykjær, J. Gliemann, I. Hermans-Borgmeyer, D. Kuhl, C. M. Petersen, G. Hermey. Different Motifs Regulate Trafficking of SorCS1 Isoforms. Traffic 2008; 9: 980-94.

  • M. Mari, M.V. Bujny, D. Zeuschner, W.J.C. Geerts, J. Griffith, C.M. Petersen, P.J. Cullen, J. Klumperman, H.J. Geuze. SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic 2008; 9: 380-93.

  • P. Jansen, K. Geihl, J.R. Nyengaard, K. Teng, O. Lioubinski, S.S. Sjøgaard, T. Breiderhoff, M. Gotthardt, F. Lin, A. Eilers, C.M. Petersen, G.R. Lewin, B.L. Hempstead, T.E. Willnow, A. Nykjær. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat. Neurosci. 2007; 10: 1449-57.

  • M.S. Nielsen, C. Gustafsen, P. Madsen, J.R. Nyengaard, G. Hermey, O. Bakke, M. Mari, P. Schu, R. Pohlmann, A. Dennes, C.M. Petersen. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol. 2007; 27(19): 6842-51.

  • A. Hauburger, M. Kliemannel, P. Madsen, R. Rudolph, E. Schwarz. Oxidative folding of nerve growth factor can be mediated by the pro-peptide of neurotrophin-3. FEBS Lett. 2007; 581(22):4159-64.

  • G. Hermey, S.S. Sjøgaard, C.M. Petersen, A. Nykjær, J. Gliemann.Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members. Biochem J. 2006; 395(2): 285-93.

    • Selected publications 1996-2005

  • L. Jacobsen, P. Madsen, S.K. Moestrup, A.H. Lund, N. Tommerup, A. Nykjær, L. Sottrup Jensen, J. Gliemann, C.M. Petersen. A novel human receptor containing eleven LDL receptor class A repeats expressed predominantly in the central nervous system. J. Biol. Chem. 1996; 271: 31379-83.

  • C.M. Petersen, M.S. Nielsen, A. Nykjær, L. Jacobsen, N. Tommerup, H.H. Rasmussen, H. Røigaard, J. Gliemann, P. Madsen, S.K. Moestrup. Molecuar identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J. Biol. Chem. 1997; 272: 3599-3605.

  • N.J. Morris, S.A. Ross, W.S. Lane, S.K. Moestrup, C.M. Petersen, S.R. Keller, G.E. Lienhard. Sortilin is the major 110-kDa protein in Glut4 vesicles from adipocytes. J. Biol. Chem. 1998; 273: 3582-7.

  • J. Tauris, L. Ellgaard, C. Jacobsen, M.S. Nielsen, P. Madsen, H.C. Thøgersen, J. Gliemann, C.M. Petersen, S.K. Moestrup. The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin. FEBS Lett. 1998; 429: 27-30.

  • C.M. Petersen, M.S. Nielsen, C. Jacobsen, J. Tauris, L. Jacobsen, J. Gliemann, S.K. Moestrup, P. Madsen. Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J. 1999; 18: 595-604.

  • M.S. Nielsen, C. Jacobsen, G. Olivecrona, J. Gliemann, C.M. Petersen. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem. 1999; 274: 8832-36.

  • W. Hampe, J. Urny, I. Franke, S.A.H. Hoffmeister-Ullerich, D. Herrmann, C.M. Petersen, J. Lohmann, H.C. Schaller. A head-activator binding protein is present in hydra in a soluble and a membrane-anchored form. Development 1999; 126: 4077-86.

  • V. Navarro, S. Martin, P. Sarret, M.S. Nielsen, C.M. Petersen, J.-P. Vincent, J. Mazella. Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. FEBS Lett. 2001; 495: 100-5.

  • M.S. Nielsen, P. Madsen, E.I. Christensen, A. Nykjær, J. Gliemann, D. Kasper, R. Pohlmann, C.M. Petersen. The sortilin tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J. 2001; 20: 2180-90.

  • L. Jacobsen, P. Madsen, C. Jacobsen, M.S. Nielsen, J. Gliemann, C.M. Petersen.
    Activation and functional characterization of the mosaic receptor sorLA/LR11. J. Biol. Chem. 2001; 276: 22788-96.

  • L. Jacobsen, P. Madsen, M.S. Nielsen, W.P.M. Geraerts, J. Gliemann, A.B. Smit, C.M. Petersen. The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines the minimum requirements for GGA-binding. FEBS Lett. 2002; 511: 155-58.

  • A. Dennes, P. Madsen, M.S. Nielsen, C.M. Petersen, R. Pohlmann. The Vps10p cytoplasmic tail mediates lysosomal sorting in mammalian cells and interacts with human GGAs. J. Biol. Chem. 2002; 277: 12288-93.

  • G. Hermey, S.J. Keat, P. Madsen, C. Jacobsen, C.M. Petersen, J. Gliemann Characterization of SorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. J. Biol. Chem. 2003; 278: 7390-96.

  • P. Sarret, P. Krzykowski, L. Segal, M.S. Nielsen, C.M. Petersen, J. Mazella, T. Stroh, A. Beaudet. Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system. J. Comp. Neurol. 2003; 461(4): 483-505.

  • S.G. Conticello, N.D. Kowalsman, C. Jacobsen, G. Yudkovsky, K. Sato, Z. Elazar, C.M. Petersen, A. Aronheim, M. Fainzilber. The pro-domain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors. J. Biol. Chem. 2003; 278: 26311-14.

  • A. Nykjær, R. Lee, K.K. Teng, P. Jansen, P. Madsen, M.S. Nielsen, C. Jacobsen, M. Kliemannel, E. Schwarz, T.E. Willnow, B.L. Hempstead, C.M. Petersen. Sortilin is essential for proNGF-induced neuronal cell death. Nature 2004; 427: 843-48.

  • J. Gliemann, G. Hermey, A. Nykjær, C.M. Petersen, C. Jacobsen, P.A. Andreasen. The mosaic receptor SorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochem. J. 2004; 281: 203-12.

  • U.B. Westergaard, E. Sørensen, G. Hermey, M.S. Nielsen, A. Nykjær, K. Kirkegaard, C. Jacobsen, J. Gliemann, P. Madsen, C.M. Petersen. Functional organization of the Sortilin Vps10p-domain. J. Biol. Chem. 2004; 279: 50221-29.

  • A. Nykjær, T.E. Willnow, C.M. Petersen. p75NTR – To live or let die. Curr. Opin. Neurobiol. 2005; 15: 1-9.

  • U.B. Westergaard, K. Kirkegaard, E.S. Sørensen, C. Jacobsen, M.S. Nielsen, C.M. Petersen, P. Madsen. SorCS3 does not reguire propeptide cleavage to bind nerve growth factor. FEBS Lett. 2005: 579: 1172-76.

  • O.M. Andersen, J. Reiche, V Schmidt, M. Gotthardt, R. Spoelgen, J. Behlke, C.A. von Arnim, T. Breiderhoff, P. Jansen, X. Wu, K.R. Bales, R. Cappai, C.L. Masters, J. Gliemann, E.J. Mufson, B.T. Hyman, S.M. Paul, A.Nykjær, T.E. Willnow. Neuronal sorting protein related receptor SorLA/LR11 regulates processing of the amyloid protein. Proc. Natl. Acad. Sci. USA 2005; 102: 13461-6.

  • H.K. Teng, K.K. Teng, R. Lee, S. Wright, S. Tevar, F. Lee, Z. Chen, R. Kraemer, A. Nykjær, B.L. Hempstead J. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and Sortilin. Neuroscience 2005; 25: 5455-63.